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The 2023 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center is headed for its quarterfinal round. The excitement is building as some of the world's favorite players inch closer toward this prestigious hardcourt title.

Novak Djokovic is currently ranked second in the world after winning the 2023 French Open and finishing as the runner-up to Carlos Alcaraz in this year’s Wimbledon tournament.

Alcaraz, the defending U.S. Open champion, eliminated Italy’s Matteo Arnaldi to reach this year’s final eight. He is one of his sport’s hottest talents right now, and expectations are running high for him to appear in another Grand Slam event final.

Also in the quarterfinals, Frances Tiafoe and Ben Shelton will meet in an all-USA clash that should be a superb spectacle for local fans. No matter the result, an exceptionally talented young American is guaranteed to appear in the semifinals later this week.

Here are our U.S. Open best bets for the upcoming men’s quarterfinals as we take a closer look at Novak Djokovic’s match and the showdown between two Americans vying for a spot in the final four.

Novak Djokovic vs Taylor Fritz Odds, Moneyline & Spread – US Open Betting Men’s Odds 9/5

Match Winner: Novak Djokovic -650, Taylor Fritz +450
1st Set Winner: Novak Djokovic -400, Taylor Fritz +250
2nd Set Winner: Novak Djokovic -400, Taylor Fritz +250
Total Games:
(31.5) Over -167, Under +120
(32.5) Over -138, Under +100
(33.5) Over -118, Under -118
(34.5) Over -112, Under -125
(35.5) Over +110, Under -154
Novak Djokovic vs Taylor Fritz Prediction and Pick

Second-seeded Novak Djokovic beat ninth-seeded Taylor Fritz just last month in straight sets at the Cincinnati Masters. The Serbian went on to win that competition, and his victory over Fritz kept him a perfect 7-for-7 in his matches against the American.

Fritz has been steadily rising through the ranks and in 2023 is finally poised to start challenging for major titles. Already one of the world’s top 10 players, Fritz couldn’t ask for a better way to announce his arrival than by eliminating a three-time U.S. Open champion in the tournament’s quarterfinals.

Fritz is rapidly improving as a tennis player with a powerful forehand and one of the best first serves in the game, but Djokovic is competing at an unstoppable level right now. His 2023 performance is as good as it has ever been, resulting in titles at both the French Open and Australian Open, as well as a trip to this year’s Wimbledon final.

Djokovic is the clear favorite among sportsbooks for this match with U.S. Open tennis betting odds of -650 to win it. He was at the very top of our best bets in our U.S. Open preview, and based on his current play, he appears headed toward yet another Grand Slam event’s final.

In seven total matches against Djokovic, Fritz has won only two sets. Both came in a five-set thriller at the 2021 Australian Open. I’m picking Fritz to claim one set in this week's quarterfinal, but I expect Djokovic to win the match 3-1.

The Pick: Novak Djokovic to win match 3-1 (+250)

Frances Tiafoe vs Ben Shelton Odds, Moneyline & Spread – US Open Betting Men’s Odds 9/5

Match Winner: Frances Tiafoe -650, Ben Shelton +450
1st Set Winner: Frances Tiafoe -400, Ben Shelton +250
2nd Set Winner: Frances Tiafoe -400, Ben Shelton +250
Total Games:
(31.5) Over -167, Under +120
(32.5) Over -138, Under +100
(33.5) Over -118, Under -118
(34.5) Over -112, Under -125
(35.5) Over +110, Under -154
Frances Tiafoe vs Ben Shelton Prediction and Pick

At just 20 years old, unseeded Ben Shelton has reached the quarterfinals in both the men's singles and mixed doubles tournaments at this year’s U.S. Open. He will be the youngest American man to play in the singles quarterfinals since tennis icon Andy Roddick was there back in 2003. Tennis fans are very excited about this young prospect’s future. 

He will go up against fellow American Frances Tiafoe, the tournament’s 10th seed. Tiafoe made an impression at last year’s U.S. Open by reaching the semifinals -- beating Rafael Nadal along the way. He lost in the 2022 semis to Spanish world No. 1 Carlos Alcaraz, who went on to win the tournament.

During a respectful press conference to discuss his quarterfinal appearance, Tiafoe mentioned that he wants to keep Shelton on his toes by making him hit a lot of balls. Supported by a wicked serve and high energy levels, Tiafoe plans to play a tough, enduring game that might tire out Shelton. Tiafoe also shared that he likes playing against left-handed opponents and appeared very confident heading into the match.

Shelton has nothing to lose, and while the two have a friendly relationship, I don’t doubt that the younger player would love nothing more than to beat Tiafoe in his country’s premier tennis event.

These two players are familiar with each other, and while Tiafoe has more experience and holds the firm upper hand, Shelton is playing exceptionally well at the moment. I have this one going to at least four sets, and a five-set thriller would certainly give the crowd its money's worth. The U.S. Open tennis odds heavily favor Tiafoe, and while he might win, Shelton will be determined to give him a tough time along the way.

The Pick: Tiafoe vs. Shelton Over 3.5 Sets (-182)

Carlos Alcaraz vs Alexander Zverev Odds, Moneyline & Spread – US Open Betting Men’s Odds 9/5

Match Winner: Carlos Alcaraz -450, Alexander Zverev +325 1st Set Winner: Carlos Alcaraz -334, Alexander Zverev +220 2nd Set Winner: Carlos Alcaraz -300, Alexander Zverev +200 Total Games: (34.5) Over -143, Under +105 (35.5) Over -125, Under -112 (36.5) Over -112, Under -125 (37.5) Over +100, Under -138 (38.5) Over +110, Under -154

Carlos Alcaraz vs Alexander Zverev Odds, Moneyline & Spread – US Open Betting Men’s Odds 9/5

Match Winner: Carlos Alcaraz -450, Alexander Zverev +325
1st Set Winner: Carlos Alcaraz -334, Alexander Zverev +220
2nd Set Winner: Carlos Alcaraz -300, Alexander Zverev +200
Total Games:
(34.5) Over -143, Under +105
(35.5) Over -125, Under -112
(36.5) Over -112, Under -125
(37.5) Over +100, Under -138
(38.5) Over +110, Under -154

Carlos Alcaraz vs Alexander Zverev Predictions and Pick

Carlos Alcaraz flew through his round of 16 matchup against Matteo Arnaldo in under two hours, winning in straight sets as he looks to defend his US Open title in New York this month.

The world number one came into this tournament having won the previous Grand Slam of 2023 at Wimbledon earlier this summer, and is now hoping to become the first player to defend his US Open title since Roger Federer won the competition five straight times between 2004 and 2008.

His opponent, however, has beaten Alcaraz on hard courts every time they’ve played. German Alexander Zverev is currently 3-2 against the Spaniard, with Alcaraz’s two wins both coming on clay.

While Zverev leads the head-to-head, the two haven’t played on a hard court surface for a while, and Carlos Alcaraz has become one of the greatest players in world tennis over the last couple of years.

The Spanish defending champion is the clear favorite, and the fact that Zverev’s win in the previous round lasted over four hours while Alcaraz was done in two certainly could play a factor. I have Alcaraz winning this one, but Zverev making it a contest. It could go to five sets, but for value versus risk we’ll take four.

The Pick: Alcaraz vs Zverev Over 3.5 Sets (-134)

Best US Open Tennis Parlays Bets for the Men’s Quarterfinal Round: 3-Leg Parlay Picks (+930)

Set Betting

Leg-1 Parlay Pick: Novak Djokovic to win 3-1 (+250)

Total Sets

Leg-2 Parlay Pick: Tiafoe vs. Shelton over 3.5 Sets (-182)

Total Sets

Leg-3 Parlay Pick: Alcaraz vs Zverev Over 3.5 Sets (-134)

Odds are subject to change*

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