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Best NFL Parlay Picks for Week 6: 4-Leg Parlay Pick (+1540)

Leg-1 Pick: Miami Dolphins -13.5 (-110)

Leg-2 Pick: Chicago Bears to win (+120)

Leg-3 Pick: Houston Texans to win (+100)

Leg-4 Pick: Los Angeles Rams -7 (-110)

NFL Week 6: Picks, Predictions & Schedules

NFL Schedule Week 6 – Game info - Panthers at Dolphins
2023 NFL Regular Season Game
Carolina Panthers (0-5) vs. Miami Dolphins (4-1)
Date: Sunday, Oct. 15
Time: 1 p.m. ET
Venue: Hard Rock Stadium in Miami Gardens, Fla.
TV Channel: CBS
Live Stream: fuboTV, NFL+

The Miami Dolphins are now 4-1 for the first time since 2003 after their win over the New York Giants last weekend. On Sunday, they will face a visiting Carolina team that is struggling at the other end of the NFL rankings. The hapless Panthers are winless at 0-5 as they experience growing pains under a new coaching staff while a rookie quarterback runs their offense.

This matchup favors the Dolphins, even though Miami has lost standout rookie running back De’Von Achane to a knee injury. He will miss at least four weeks on Injured Reserve, but even without him Miami still looks like it possesses one of the NFL’s most dangerous offenses.

Panthers vs. Dolphins Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 6

Moneyline: Carolina Panthers +600, Miami Dolphins -900
Spread: Panthers +1.5 (-110), Dolphins -13.5 (-110)
Total: Over/Under 48.5 points

Panthers at Dolphins Preview

The Carolina Panthers haven’t exactly had the dream start to the 2023 season that their fan base might have been hoping to see. While rookie quarterback C.J. Stroud has been lighting up the NFL and setting records in Houston, Panthers rookie QB Bryce Young has struggled, and Carolina’s offense has been lackluster in just about every category this season.

Young, the No. 1 pick in the 2023 NFL Draft, has been underwhelming, but the Panthers’ struggles are hardly his fault alone. Any rookie quarterback is expected to face a transition period adjusting to life in the pros, and Young has the misfortune of being part of an offense that has failed to establish a consistent run game and can’t get anybody open downfield.

The Panthers paid running back Miles Sanders in the offseason, but his 2023 contribution has been tremendously underwhelming behind an offensive line that isn’t clicking as it needs to just yet. Sanders has not rushed for more than 32 yards in any of his last three starts, and his carries-per-game number has dipped below 10 twice in that timeframe.

Sanders was also brought in as a potential safety valve in the passing game for Young. However, in Week 5, Sanders wasn’t targeted even once, and so far this season he has only 15 catches for 81 yards.

Veteran wide receiver Adam Thielen has been about the only good thing in the Panthers offense so far this season. Thielen has caught passes for 394 yards and three touchdowns, leading the team in both categories and proving why he has lasted so long at football’s highest level.

Carolina’s sputtering offense will attempt to go head-to-head with star QB Tua Tagovailoa and the Dolphins on Sunday. Miami is thriving offensively and setting records that eclipse the accomplishments of the “Greatest Show on Turf” Rams teams from the early 2000s.

Miami’s 2,568 yards of total offense is the single highest number in NFL history through a regular season’s first five games. The Dolphins have four of the fastest players in the game in Tyreek Hill, Jaylen Waddle, De’Von Achane, and Raheem Mostert, while Tua Tagovailoa leads the league with 1,614 passing yards.

This Dolphins team is doing things we haven’t seen in the NFL for quite some time. Miami combines its pre-snap motion and ability to cause misalignments and confusion for defenses with the flat-out speed of its wide receivers and running backs. The result is devastating to opposing defenses, and only the Buffalo Bills managed to slow this team down over its first five games.

Carolina’s defense is one of the league's best against the pass -- allowing just 185 passing yards per game, but the Panthers have not yet faced an offense like Miami’s. Indeed, no team will be able to fully prepare for the Dolphins’ unique style before it takes the field against them.

Panthers at Dolphins Prediction and Pick Week 6

I’m backing the Dolphins to win this one comfortably. Their defense has been disappointing so far this season, but it did emerge in Week 5 against the Giants with plenty of QB pressure and a standout performance from linebacker Andrew Van Ginkel.

Carolina really needs to find some rhythm. Having an offense that can’t get it together against one breaking records that have stood for decades is quite the mismatch.

I think Miami clears the spread in what could be another momentous outing for one of the AFC’s emerging favorites this Sunday.

The Pick: Miami Dolphins -13.5 (-110)

NFL Schedule Week 6 – Game info - Vikings at Bears

2023 NFL Regular Season Game
Minnesota Vikings (1-4) vs. Chicago Bears (1-4)
Date: Sunday, Oct. 15
Time: 1 p.m. ET
Venue: Soldier Field in Chicago, Ill.
TV Channel: FOX
Live Stream: fuboTV, NFL+

The Detroit Lions are currently dominating the NFC North while the Green Bay Packers, Chicago Bears, and Minnesota Vikings each face their own struggles. Two of the division’s struggling teams will face off on Sunday when Chicago hosts a Minnesota squad that just lost its superstar for the next four weeks.

Vikings vs. Bears Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 6

Moneyline: Minnesota Vikings -140, Chicago Bears +120
Spread: Vikings -2.5 (-115), Bears +2.5 (-105)
Total: Over/Under 44.5 points

Vikings at Bears Preview

It has been a rough start to the season for Minnesota and Chicago fans, whose favorite teams are currently tied at the bottom of the NFC North with 1-4 records.

In Minnesota’s case, things went from bad to worse this week when wide receiver Justin Jefferson pulled up in a Week 5 matchup with a hamstring injury that ultimately landed him on Injured Reserve. The Vikings, who have just one win through five weeks, will be forced to play another four weeks without their most talented player.

With Jefferson out, Minnesota needs both veteran receiver K.J. Osborn and rookie receiver Jordan Addison to step up in a major way. Vikings tight end T.J. Hockenson has been great so far this season, but the wideouts need to produce more yardage. Osborn had five catches for 49 yards in Week 5 against the Chiefs, and Addison has been a viable deep-threat multiple times this season with three touchdowns in the four games he has played.

Addison can expect to see an increased volume of targets in Jefferson’s absence. He’ll also get a far higher snap count as one of the team’s top two options at wideout.

Although Minnesota is favored, this weekend's matchup against Chicago is a sort of trap game for the Vikings, since Chicago has been trending upward in the past two weeks while Minnesota is trending way down. Bears quarterback Justin Fields has had his struggles, but he has thrown eight touchdown passes over the past two games and will now play against a Vikings defense that has allowed the NFL’s third-highest QBR through the season’s first five weeks.

Chicago was the laughingstock of the NFL by Week 3. Fields was missing wide-open touchdowns, while offensive coordinator Luke Getsy and his staff were drawing up some of the most horrific plays we’ve seen in recent memory. That included back-to-back, identical HB screens on their own goal line. The second pass was picked off by Tampa Bay linebacker Shaq Barrett for the easiest touchdown he’ll ever score.

Fast forward here to Week 6, and a reborn Chicago team seems to have torn up its old gameplan and started over. Fields has been far more effective at letting the ball go and trusting his eyes, and the result has been more than 600 passing yards and eight touchdown passes in the last two games alone.

This matchup favors the Bears’ young quarterback. Now, with some momentum in Fields’ corner, Chicago should absolutely be going into this game as the more confident team. Running back Khalil Herbert has had two strong games on the ground, and wide receiver DJ Moore is finally getting the service he should as a standout play-maker in this Chicago offense.

Vikings at Bears Prediction and Pick Week 6

I’ve got the Bears winning this one, and if Justin Fields plays like he has over the past two weeks it could get ugly for the Vikings.

Minnesota will likely force targets to T.J. Hockenson as its most reliable pass-catcher, and Jordan Addison will be expected to pick up some of the slack resulting from Justin Jefferson’s absence.

While I expect big things from Addison in his NFL future, trying to learn how to live without Jefferson on the fly is no easy task. Chicago should smell blood in the water here and has a very real chance at getting one over on a division rival this Sunday.

The Pick: Chicago Bears to win (+120)

NFL Schedule Week 6 – Game info - Saints at Texans

2023 NFL Regular Season Game
New Orleans Saints (3-2) vs. Houston Texans (2-3)
Date: Sunday, Oct. 15
Time: 1 p.m. ET
Venue: NRG Stadium in Houston, Texas
TV Channel: FOX
Live Stream: fuboTV, NFL+

Houston’s C.J. Stroud has been one of the most impressive quarterbacks in the NFL this season, full stop. Forget the rookie class, or any comparison to Carolina’s Bryce Young (which Stroud is clearly winning). Stroud has been good enough to be a top 10 NFL quarterback through the season’s first five weeks, and Texans fans are very, very excited.

Houston gets a visit from the New Orleans Saints on Sunday as Stroud will go up against one of the league's best pass defenses. The question is who comes out on top?

Saints vs. Texans Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 6

Moneyline: New Orleans Saints -120, Houston Texans +100
Spread: Saints -1.5 (-110), Texans +1.5 (-110)
Total: Over/Under 42.5 points

Saints at Texans Preview

The New Orleans Saints rebounded from back-to-back losses by shutting out the New England Patriots on the road in Week 5. The Saints’ 34-0 victory marked the first time Patriots head coach Bill Belichick ever lost a home game by more than 30 points, and it was just the third shutout of his Patriots coaching career.

The Patriots, of course, are dealing with many of their own offensive struggles, but that takes nothing away from what New Orleans accomplished. The Saints defense is very talented, and one of the NFL’s most well-rounded units with excellent play against both the run and pass.

Houston quarterback C.J. Stroud has yet to throw his first interception as a pro, and he now holds the record for the most pass attempts without an interception to start an NFL career. This Sunday’s game will be a real test for the rookie, who has completed 61 percent of his passes for a total of 1,461 yards and seven touchdowns.

Texans receivers Nico Collins and Tank Dell have both had big games with their new quarterback, and Collins in particular is looking like the WR1 that many fantasy football managers believed he could be coming into the year.

The Saints have been boosted by the return of running back Alvin Kamara, who has had a major impact on both the running and passing attack since coming back in Week 4. He adds to a group of pass-catchers that includes Chris Olave and Michael Thomas, giving quarterback Derek Carr plenty of talent to work with for the rest of the season.

That said, the Saints’ passing game has been a little underwhelming so far. Carr hasn’t had the most explosive games, and each game has seen multiple drives frustratingly end in a punt or a field-goal attempt. Carr hasn’t cleared 200 passing yards since Week 2, and he’s playing at less than 100 percent with a nagging shoulder injury.

I think Stroud might surprise a few analysts this week. The fact that he’s facing a great defense is a problem, and the Texans’ banged-up offensive line having to protect him from one of the most experienced pass rushes in football won’t help.

Despite these obstacles, Stroud is getting the ball out, playing decisive football and -- more than anything else -- appears to be playing with complete confidence both in himself and the scheme in which he operates. That makes him dangerous against just about anybody.

Saints at Texans Picks and Prediction

I’m picking the Texans to win. Even if the Saints defense gets to Stroud once or twice, this Houston offense has been more efficient than the Saints’ unit.

The Texans are playing at home, C.J. Stroud isn’t turning the ball over, and even though it might be somewhat of a low-scoring game, I have the Texans pulling out a win.

The Pick: Houston Texans to win (+100)

NFL Schedule Week 6 – Game info - Cardinals at Rams

2023 NFL Regular Season Game
Arizona Cardinals (1-4) vs. Los Angeles Rams (2-3)
Date: Sunday, Oct. 15
Time: 4:25 p.m. ET
Venue: SoFi Stadium in Inglewood, California
TV Channel: FOX
Live Stream: fuboTV, NFL+

Week 6 features a battle of the NFC West basement with the Los Angeles Rams and visiting Arizona Cardinals facing off at SoFi Stadium.

Arizona is just 1-4 and coming off its troubling 34-20 home loss to the previously struggling Cincinnati Bengals. Meanwhile, the Rams also fell short last weekend in a relatively close game against Philadelphia.

Cardinals vs. Rams Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 6

Moneyline: Arizona Cardinals -120, Los Angeles Rams +100
Spread: Cardinals +7 (-110), Rams -7 (-110)
Total: Over/Under 48.5 points

Cardinals at Rams Preview

Last Sunday at home against Cincinnati, the Arizona Cardinals made mistakes they hadn’t previously been making this season. Arizona turned the ball over multiple times, including a goal-line interception that resulted in a pick-six for Bengals cornerback Cam Taylor-Britt.

All things considered, Arizona QB Josh Dobbs has been great this year, but last Sunday was not his day, as he completed just 47 percent of his passes. He did throw two touchdowns, but that was matched by two interceptions on a day when the Cardinals fell short.

To make matters worse, Cardinals head coach Jonathan Gannon’s defense allowed 34 points against a Joe Burrow-led Bengals offense that had struggled tremendously in its first few games of the season.

Cincinnati was missing receiver Tee Higgins, but the Arizona defense allowed Ja’Marr Chase to reach 192 receiving yards and three touchdowns, marking a huge day for the Bengals receiver and a day to forget for the Cardinals defense.

Sunday brought Cardinals football back down to earth. Arizona is starting a journeyman quarterback who has barely been in the building as long as he’s been the starter, and its defense has little to no veteran leadership, plus a very young secondary. They were expected to struggle, and on Sunday they did.

In their loss to the undefeated Philadelphia Eagles last Sunday, the Rams were boosted by the return of wide receiver Cooper Kupp, who will now pair with Puka Nacua in what could be one of the NFL’s most exciting WR duos this season. The pair combined for 189 receiving yards and a touchdown against the Eagles, and they could be a real problem for the Cardinals’ defense in Week 6.

Clearly, Los Angeles head coach Sean McVay and Co. are thrilled with the Kupp-Nacua partnership, since the team traded away former second-round pick Van Jefferson on Tuesday. The Rams swapped late-round draft picks with Atlanta in the deal. Jefferson found himself almost completely unused after the emergence of Nacua, and he’ll now get a fresh start with the Falcons, who add some much-needed depth.

The Rams’ secondary lacks experience, much like Arizona’s, but as a unit the L.A. defense is performing better than many had expected this year, given the amount of turnover and veteran leadership that left town.

Los Angeles is a well-coached team, and this weekend feels like an opportunity for Rams QB Matt Stafford and his receivers to put up some numbers against the Cardinals, who could struggle to keep up with them.

The Cardinals’ loss of running back James Conner to Injured Reserve is a major blow for the team’s offense, which must now rely on a combination of Keaontay Ingram and rookie Emari Demercado to provide a ground game.

Cardinals at Rams Predictions and Pick

This one could get away from the Cardinals, which is how I see it going, since the Rams’ passing game can now call on two major play-makers. They have found a real gem in Puka Nacua, and Cooper Kupp should only complement Nacua’s game rather than hinder it.

I have the Rams winning comfortably, and covering the spread in the process.

The Pick: Los Angeles Rams -7 (-110)

Odds are subject to change*

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