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We have entered the conference-play portion of the 2023-24 NCAA basketball season, which is when things really get interesting. The early-season, non-conference schedules brought many great matchups, but there’s nothing better than traditional rivalry games as well as a chance to see how some teams fare in their new conferences. We have a fully loaded schedule on Wednesday night, so let's jump in and break down some key games.

Best College Basketball Parlays Today - Wednesday, Dec. 20: 4-Leg Parlay Picks (+445)

Baylor vs. Duke Prediction and Pick

After appearing to be one of the best teams in college basketball, No. 10 Baylor (9-1) suddenly looked like one of the worst teams when it played at Michigan State on Saturday. The Bears’ 88-64 loss to the Spartans was their worst defeat since November 2022, when Marquette beat them 96-70. No. 21 Duke has also had a good start to its season, but the Blue Devils have hit some bumps along the way.  A 72-68 loss at Georgia Tech was not good for their resume. Duke also lost at Arkansas on Nov. 29 and at home against Arizona on Nov. 10, but the Razorbacks have been a sneaky team this year, while the Wildcats are one of the best teams in the country.

Wednesday night’s game will be played at Madison Square Garden in New York, so the neutral site won’t give either team a home-court advantage. One potential advantage for Duke is how it performed against Michigan State – the only team that has beaten Baylor so far this season. While Baylor lost to the Spartans just four days ago, Duke defeated them 74-65 on Nov. 14. There are times when looking at how teams fared against a common opponent can help predict the outcome of a game, but that shouldn’t be the case here.

The bottom line is that Baylor is a better team than Duke. Turnovers and a terrible first half were the reason why the Bears fell at Michigan State, which had a 45-17 lead at halftime. Look for Baylor to bounce back in this one as guard Rayj Dennis and future NBA Draft lottery pick Ja’Kobe Walter will lead Baylor to victory at MSG.

Leg-1 Parlay Pick: Baylor ML (+135)

Xavier vs. St. John’s Prediction and Pick

On a night when many high-profile teams are going head-to-head, it’s OK to look beyond the spotlight for better wagering opportunities. That’s why we shift from Manhattan to Queens for the second leg of this parlay. The Xavier Musketeers have been tested this season by a tough non-conference schedule featuring games against Purdue, Washington, St. Mary’s, and Houston. Xavier went 2-2 over those four games and showed it can hang with college basketball’s big dogs this season. On the other hand, Big East rival St. John’s hasn’t faced any teams of that caliber so far, but if the Red Storm had, they certainly would have answered the call because this St. John’s team is loaded with talent. All five Red Storm starters are averaging double-digit point totals, and St. John’s can beat opponents in several different ways. The absence of injured guard RJ Luis has certainly hindered this team, but St. John’s head coach Rick Pitino has said that his young star will return to practice next week and likely be back in the lineup soon. Luis could have made this game a lopsided affair, but St. John’s still has enough talent to beat Xavier on Wednesday night.

Leg-2 Parlay Pick: St. John's ML (-250)

Connecticut vs. Seton Hall Prediction and Pick

Connecticut and Seton Hall will meet on Wednesday night in what will be both teams’ first Big East game of the 2023-24 season. No. 5 UConn (10-1) has dominated its non-conference games, and the Huskies have already established themselves as one of the best teams in the country for 2023-24. Seton Hall, on the other hand, is still trying to find its way at 7-4. All four of the Pirates’ losses weren’t even competitive games, and they came against the best four teams on Seton Hall’s non-conference schedule. While big losses to top 25 teams Baylor (78-60) and USC (71-63) were understandable, not being able to compete against Iowa and Rutgers was hardly a good look for the Pirates. Wagering on the spread would not be a bad choice for this game as a single bet on Connecticut. In building a parlay, however, the opportunity to go with the Huskies as an outright winner is practically a bingo free-play.

Leg-3 Parlay Pick: Connecticut ML (-400)

Radford vs. West Virginia Prediction and Pick

I have been backing West Virginia with so much enthusiasm this season that one might think my first-born child is on the Mountaineers’ roster. Well, this team is only 4-6, but I’m not going to stop singing its praises for one second. The loss of center Jesse Edwards to a fractured right wrist will certainly hurt the Mountaineers, but the talents of guards Kobe Johnson and Kerr Kriisa, along with forward Quinn Slazinski, are more than enough to ensure that West Virginia will remain competitive until Edwards gets back. Radford’s non-conference schedule to this point hasn’t brought much quality competition other than a date with James Madison – the team that spoiled Michigan State’s opening night. Radford played JMU down to the wire on the road before losing 76-73. The Highlanders are a good small-conference team, but they will not be able to play the spoiler role in Morgantown. Give me West Virginia to close out this parlay.

Leg-4 Parlay Pick: West Virginia ML (-300)

NCAAB PARLAY PICKS @(+445 odds): (Bet $100 to Win $545)

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