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Philadelphia Union to beat Minnesota United (-120)

Philadelphia Union finished the MLS 2021 regular season with the second-best home record, winning 11 and drawing three of their 17 matches.

Two of those home defeats for the Union came against MLS Cup champions New York City and Supporters’ Shield winners New England Revolution.

They can keep that impressive form going in their opener against a Minnesota team that won three out of 17 on the road in 2021.

LAFC to beat Colorado Rapids (-150)

LAFC come into this a different prospect than the team that missed out on the playoffs in the Western Conference last season.

The Black and Gold have replaced Bob Bradley with former Las Vegas Lights coach Steve Cherundolo and strengthened their roster in the off-season, with highly-rated players Maxime Crepeau, Franco Escobar, Ismael Tajouri-Shradi and Eduard Atuesta all joining.

Colorado has already been in action this season, losing on penalties to Guatamalan side Comunicaciones after two legs in the CONCACAF Champions League, and has lost key players Kellyn Acosta and Cole Bassett in the off season.

Austin FC to beat FC Cincinnati (-160)

FC Cincy have finished last in the Eastern Conference in each of the three years they have been a part of the MLS.

In that period, they have lost 59 and won just 14 of the 91 matches they have played.

Austin couldn’t have asked for a kinder opening weekend fixture in their second season in the MLS and should be able to build on the four victories in five at home they finished 2021 with.

Inter Miami to beat Chicago Fire (+105)

Finishing 11th in the Eastern Conference was a disappointing result for Inter Miami in 2021, but a handful of new players can help them be a force this season.

With DeAndre Yedlin being one of a handful of names to join Blaise Matuidi and Gonzalo Higuain, Phil Neville’s team have the highest-profile roster in the MLS with potential to do some damage.

Chicago Fire lost 13 and won just two out of 17 on the road last season.

DC United to beat Charlotte FC (-160)

DC United had the sixth-best home record in the MLS during the 2021 season, winning 11 and drawing one of their 17 matches.

The Black-and-Red have changed coach since missing out on the playoffs last term, and are rightly favorites against the latest expansion team.

Charlotte FC are North Carolina’s first-ever professional soccer team, but as Austin FC, Inter Miami and FC Cincinnati prove, it will likely take time for them to compete anywhere above the bottom places.