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NFL Schedule Week 3 – Game info

2023 NFL Regular Season Game
New York Giants (1-1, 1-0 Away) vs San Francisco 49ers (2-0, 0-0 Home)
Date: Thursday, Sept. 21
Time: 8:15 p.m. ET
Venue: Levi’s Stadium in Santa Clara, Calif.
TV Channel: Amazon Prime
Live Stream: Amazon Prime
Live Radio: WFAN-FM 101.9 (660AM)

Thursday Night Football returns to Amazon Prime live from Levi’s Stadium, where San Francisco will host the New York Giants in the 49ers’ home opener. The first six quarters of their NFL season were 90 minutes to forget, but the Giants rebounded to beat Arizona in the second half last Sunday. They will now look to play a spoiler role in prime time against the 49ers. Let’s check out some prime-time best bets for this Thursday night game.

Giants vs 49ers Odds, Spread, Moneyline, Over/Under - NFL Odds Week 3

Moneyline: New York Giants +400, San Francisco 49ers -550
Spread: Giants +10.5 (-115), 49ers -10.5 (-105)
Total: Over/Under 44.5 points

Giants at 49ers Preview 

The New York Giants became the first NFL team in 45 years to give up at least 60 points before scoring their first points of the season last Sunday, when they fell behind the Arizona Cardinals 20-0 at halftime. It was pure turmoil for the Giants, who were shut out 40-0 by the Dallas Cowboys in Week 1. Although New York flipped the script and came back to win with 31 second-half points, the Giants should hardly get too excited about beating a weak Arizona team. Meanwhile, the San Francisco 49ers, who had defeated the Pittsburgh Steelers 30-7 in Week 1, struggled a bit with the Los Angeles Rams’ quick passing attack but still managed to come away with a 30-23 win. After two weeks on the road, the 49ers finally get to play their home-opener on Thursday night, and they will be licking their chops to take a bite out of the Giants. 

Giants vs 49ers Predictions and NFL Picks Week 3

Predicting the total points for this game is tricky, because the Giants’ offense has only looked good for two quarters so far this season, and their defense has been Swiss cheese. Playing without star running back Saquon Barkley -- and down two starting offensive lineman in Andrew Thomas and Ben Bredeson -- the Giants will have their hands full against a top-tier San Francisco defense. The 49ers have scored 30 points in each of their first two games, and running back Christian McCaffrey is looking like the “Run CMC” that we all know with 268 rushing yards and two touchdowns through his first two games. Another shutout is not out of the question for this Giants team, which will struggle to move the ball. New York’s defense will also struggle, because it’s allowing opponents 136.5 rushing yards per game -- the seventh-highest total in the NFL. The Giants also allow the most points per game at 34.0. Since this is San Francisco’s home opener, it wouldn’t surprise me to see the 49ers put up 40-plus points on Thursday, making the total a near coin flip.

The Pick: Over 44.5 (-105)

The first two Thursday night games certainly shocked NFL fans, because the Kansas City Chiefs were upset by the Detroit Lions and Minnesota Vikings quarterback Kirk Cousins dominated a prime-time game that his team lost. This week, nobody is going to be shocked by the Thursday night result. This will be a beatdown from start to finish, and the the 49ers’ home opener will truly be a party for San Francisco fans. The Niners have the better defense and the better offense. They also probably have the 10 best players on the field apart from Giants tight end Darren Waller, whom one could argue belongs in that conversation. The 49ers will easily win this game by 10 or more points.

The Pick: San Francisco 49ers -10.5 (-105)

Best NFL Player Prop Bets for Giants vs 49ers: Thursday Night Football Week 3

Christian McCaffrey

San Francisco running back Christian McCaffrey has rushed for 268 yards on 42 carries through his first two games, having also scored two touchdowns. Statistically, the Pittsburgh Steelers have allowed many more rushing yards than the Giants through two games, but the Steelers also had to face McCaffrey and Cleveland’s Nick Chubb.  McCaffrey had at least 20 carries in the 49ers’ wins over Pittsburgh and the Rams, rushing 22 times against the Steelers. Even though this is San Francisco’s home opener and a blowout is likely, McCaffrey will still get his fair share of carries. This yardage prop is too low even if McCaffrey stays in the 15-attempts range.

The Pick: Christian McCaffrey over 79.5 rushing yards (-120)

Best Same Game Parlay Week 3 bets today for Giants vs 49ers: 3-Leg Parlay Pick (+380)

Christian McCaffreyYes I’m going Christian McCaffrey heavy in this one as I can definitely see him breaking a big run in this game. His longest run in week one was 65 yards that resulted in a touchdown and his longest run in week two was 51 yards. This Giants defense has yet to allow a single run for over 25 yards but they haven’t played a running back like McCaffrey yet either. Not that this prop is dependent on a long run either, as 5.25 yards per carry gets it done if he gets 20 attempts, but this a great prop to get our same game parlay going.

Leg-1 SGP Pick: Christian McCaffrey over 104.5 rushing yards (+250)

49ers Points ScoredIf for some reason this game is close, the Giants are going to have to find ways to score as the 49ers will have no problems scoring against their defense. The Giants allow the most points per game to opposing teams through the first two games at an average of 34 points per game. The 49ers getting over 27.5 points seems very doable in their home opener.

Leg-2 SGP Pick: 49ers points scored over 27.5 (-110)

Money Line
The San Francisco 49ers are going to win this game big and the entire world knows that. I do not believe in jynxs but I will remain conservative with this pick as it’s essentially the free play spot in bingo. If you want to juice up this same game parlay by taking the 49ers with a spread go right ahead, but sometimes it’s nice to not have to sweat a pick and this is it.

Leg-3 SGP Pick: San Francisco 49ers ML (-575)

Odds are subject to change* 

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