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Jimmy Garoppolo over 240.5 passing yards (-110)

The 49ers have been willing to throw the ball when they face teams with good run defenses. That is exactly what they’ll see in their matchup against the Titans, with Tennessee allowing only 3.9 yards per carry.

Garoppolo will be passing against a suspect secondary, and has passed for over 290 yards in three of his last four road games, with the one failed attempt being a blowout against the Jaguars. 

George Kittle over 69.5 receiving yards (-110)

If Garoppolo is going to have success through the air, you know Kittle will be involved. The tight end has turned his play up to another level lately, totaling over 90 receiving yards in three straight weeks.

He is clearly Garoppolo’s favorite target, and when Kittle does well, so does the rest of this team. Look for the trend of him leading the 49ers in receiving to continue. 

George Kittle anytime touchdown (+130)

On top of his high yardage totals, Kittle is also finding the end zone regularly and should do again on Thursday.

Kittle has scored at least one touchdown in five of his past seven games.

Brandon Aiyuk over 47.5 receiving yards: Over 47.5 (-115)

Aiyuk is another 49ers receiver that should have success against the Titans. Tennessee has allowed the second-most receiving yards to wide receivers in the NFL, at 189.6 per game.

Aiyuk has totaled over 47.5 receiving yards in four of his past five games. He is currently operating as the team’s top wide receiver, with Deebo Samuel playing more snaps out of the backfield.