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Best College Football Parlay Picks for Week 10: 4-Leg Parlay Picks (+1610)

Leg-1 Parlay Pick: Oklahoma vs Oklahoma State Over 61.5 Points (-105)

Leg-2 Parlay Pick: Georgia Bulldogs -15.5 (-110)

Leg-3 Parlay Pick: Washington Huskies -4 (-110)

Leg-4 Parlay Pick: LSU Moneyline (+135)

CFB Parlay @ (+1610): (Bet $100 to Win $1710). Get the best odds at Betway Sportsbook

Best College Football Bets Week 10: Picks, Predictions & Schedules

College Football Schedule Week 10 – Game info - Oklahoma at Oklahoma State
College Football Season 2023
Oklahoma (7-1) vs. Oklahoma State (6-2)
Date: Saturday, Nov. 4
Time: 3:30 p.m. ET
Venue: Boone Pickens Stadium at Stillwater, Okla.
TV Channel: ABC
Live Stream: FuboTV

Oklahoma vs. Oklahoma State Odds, Spread, Over/Under, Moneyline - College Football Odds Week 10

Moneyline: Oklahoma -225, Oklahoma State +190
Spread: Oklahoma -6 (-110), Oklahoma State +6 (-110)
Total: Over/Under 61.5

Oklahoma vs. Oklahoma State Preview

The Oklahoma Sooners had their playoff hopes dashed last weekend in a 38-33 thriller against the Kansas Jayhawks. The Sooners ended up on the wrong side of a back-and-forth fourth quarter and suffered their first loss of the season. That defeat dropped Oklahoma from No. 6 to No. 10 in the AP rankings.

The Sooners will have to brush that loss off quickly because they are now about to face Oklahoma State in the last “Bedlam” game we are likely to see for some time. Oklahoma will be joining the SEC next season, bringing an end to its annual encounter with its in-state rival.

Lack of discipline was a major factor in the Sooners’ loss at Kansas last Saturday. Oklahoma’s 11 total penalties in that game cost it more than 100 yards. The Sooners turned the ball over three times, nullifying the three takeaways they had forced themselves, and they were just 2-for-10 on third-down conversions.

Oklahoma offensive coordinator Jeff Lebby faced valid criticism for the way he called that game against the Jayhawks, particularly since his team seemed timid in the face of a Kansas defense that doesn’t even rank in the nation’s top 70 against the pass or top 100 against the run.

Sooners quarterback Dillon Gabriel threw a total of only 19 passes that resulted in just 171 yards on the day. That was in stark contrast to the 14 times Gabriel ran the football on a day when OU’s primary running back, Tawee Walker, had 23 carries for 146 yards and a touchdown. 

Oklahoma State had a very different experience in its last outing, when the Cowboys dismantled the Cincinnati Bearcats 45-13 with more than 600 yards of total offense. It was one of the team’s best displays of the year, and it featured a strong performance from former Division III player Leon Johnson III, a transfer from George Fox University who announced his Division I arrival in style.

Johnson hadn’t even been targeted until last weekend, but he went out and led the team with five receptions for 149 yards against Cincinnati.

Johnson’s contribution supported the great work of OSU star running back Ollie Gordon, who had a huge weekend with 25 carries for 271 yards and two touchdowns as well as four catches for 21 yards. 

The Sooners defense will either need to slow Oklahoma State’s running game down on Saturday, or Oklahoma’s offense will need to have a highly productive day in what will be an intense road-game atmosphere against a major rival.

Oklahoma vs. Oklahoma State Predictions and Pick

Make no mistake about it, this game will feature fireworks. For neutral fans, it promises to be one of the weekend's most exciting matchups, since both teams have high-scoring offenses.

The Sooners need to come out far more aggressively this weekend than they did at Kansas. They will likely have learned from their mistakes against the Jayhawks before taking the field against OSU.

If Oklahoma’s Dillon Gabriel can get back over 300 passing yards -- as he has done four times already this season -- the Sooners should have no problem putting another 30-plus points on the board, because they have had one of the country’s highest-scoring offenses this season.

Oklahoma State will need to keep up offensively, and with their powerful running game and playmakers in the aerial attack, the Cowboys could also have a high-scoring day against a defense that just gave up 38 points to Kansas. 

I’ll take the over in this one, and will quite happily enjoy the game while hoping for plenty of points and a photo finish in the fourth quarter.

The Pick: Over 61.5 Points (-105)

College Football Schedule Week 10 – Game info - Missouri at Georgia

College Football Season 2023
Missouri (7-1) vs. Georgia (8-0)
Date: Saturday, Nov. 4
Time: 3:30 p.m. ET
Venue: Sanford Stadium in Athens, Ga.
TV Channel: CBS
Live Stream: FuboTV

Missouri vs. Georgia Odds, Spread, Over/Under, Moneyline - College Football Odds Week 10

Moneyline: Missouri +475, Georgia -700
Spread: Missouri +15.5 (-110), Georgia -15.5 (-110)
Total: Over/Under 54.5 

Missouri vs. Georgia Preview

The Missouri Tigers have really taken off this season. If I were head coach Eliah Drinkwitz at this point in the year, I’d be letting my team know that they should feel rather disrespected in terms of national media attention.

Coming off back-to-back 6-7 seasons, the Tigers are now 7-1 this year. Their only loss came late in the fourth quarter of a 49-39 shootout against LSU on Oct. 7. Missouri quarterback Brady Cook had over 400 passing yards in that game, but it wasn’t enough to secure the win. Apart from that one home loss, the Tigers have really taken care of business. They’re 3-1 in the SEC, and a Sept. 16 win over a ranked Kansas State team earned them some respect.

The question hovering over Missouri is how well this team might do against one of the nation’s top 10 programs -- a challenge they will face for the first time this weekend.

There is absolutely no denying Missouri’s talent. Cook has already surpassed his touchdown numbers from last season and he is only 300 yards shy of his 2022 passing-yardage total, too. He has had some great games this year, including throwing for 411 yards and two touchdowns against LSU. He has only been intercepted three times this season, but two of those picks came against LSU, which has one of the better defenses he has faced.

Apart from that two-interception day, Cook has done a great job finding his top two wide receivers this season. Missouri’s Theo Wease has five touchdowns as WR2, but Luther Burden is the bigger threat, and he’ll need to have a major impact on this game if the Tigers are going to be able to compete against No. 1-ranked Georgia.

Burden is one of the best recruits in the history of Missouri’s football program. He has answered the bell in every game he’s played for the Tigers since he arrived on campus last year. With 902 receiving yards and six touchdowns so far this season, he is going to be a critical part of any success the Tigers have in this weekend’s game.

As far as Georgia goes, let’s give credit where credit is due. Last week, all the noise surrounding the Bulldogs’ matchup with Florida focused on the absence of tight end Brock Bowers and how his team might not look the same offensively without him.

Georgia silenced all critics by dominating the Gators 43-20 in Jacksonville. At this point, it appears as though the Bulldogs are really in sync. If Missouri can’t throw Georgia QB Carson Beck off of his game and make him lose his rhythm, then the Tigers will have very little chance of winning here. Beck has thrown for more than 300 yards in four of his last five starts, including the 315 yards and two TDs he just dropped on Florida last weekend.

The Bulldogs have begun to peak at the midpoint of the season. In typical fashion, this No. 1 team is improving week over week heading toward the playoffs. Georgia’s defensive front seven is stuffing the run with far more success than earlier in the year, and had it not been for one breakaway run by Florida last weekend, it would have completely shut down what has been a relatively strong Gators running game.

Bowers’ absence proved to be a minor issue for the offense, which controlled the game and pulled away from Florida thanks to touchdowns from Daijun Edwards and Kendall Milton out of the backfield and from receivers Ladd McConkey and Dillon Bell in the passing attack. The Bulldogs proved they can still wear down a defense, and that could be a major issue for all upcoming opponents as the season heads toward crunch time.

Missouri vs. Georgia Predictions and Pick

I’m not sure that Missouri has enough diversity in its offense to keep up with this Georgia Bulldogs team. Other than receiver Luther Burden, who will be the primary focus of the Georgia defense, I don’t see enough big-time playmaking ability on the Tigers roster.

The Bulldogs are going to score -- likely 30-plus points -- and Missouri will struggle to run the ball at times against Georgia’s front seven. When those things happen, and the Tigers need to play from behind, Missouri QB Brady Cook is going to have to throw the football down the field and have his playmakers consistently get open just to keep up. I think the Tigers will put up a good fight but eventually fall away late in this game, allowing Georgia to cover the spread.

The Pick: Georgia Bulldogs -15.5 (-110)

College Football Schedule Week 10 – Game info - Washington at USC

College Football Season 2023
Washington (8-0) vs. USC (7-2)
Date: Saturday, Nov. 4
Time: 7:30 p.m. ET
Venue: LA Memorial Coliseum at Los Angeles, Calif.
TV Channel: ABC
Live Stream: FuboTV 

Washington vs. USC Odds, Spread, Over/Under, Moneyline - College Football Odds Week 10

Moneyline: Washington -175, USC +145
Spread: Washington -4 (-110), USC +4 (-110)
Total: Over/Under 77.5

Washington vs. USC Preview

I love the storyline for this game. It’s USC quarterback Caleb Williams, the Heisman favorite going into this year, hosting Michael Penix Jr., the Washington quarterback who has managed to steal his thunder.

Penix is now the Heisman favorite heading into this showdown, and one has to imagine that a win over Williams and the Trojans would only put him further ahead in the race for that prestigious award.

There will be plenty of points scored in this game. In fact, at the time of this writing, oddsmakers were not yet even offering an over/under total line for the game. USC has the nation’s top-scoring offense, putting up an average of just under 46 points per game, while Washington ranks seventh in the nation with 40-plus points per game.

Penix has been superb this year, and he really looks like an NFL quarterback in the Washington offense. He leads the nation in passing yards and ranks third in passing touchdowns, trailing only LSU’s Jayden Daniels and Williams, the guy he’ll face on Saturday night, who are tied for the lead with 25 TDs.

Last Saturday, the Huskies quarterback bounced back from what had been an uncharacteristic performance against Arizona State the previous weekend. One week after getting intercepted twice by the Sun Devils, Penix managed to to throw for 369 yards and four touchdowns against Stanford, which picked him off only once.

Penix has thrown for at least four touchdowns in five games this season, and this USC defense simply doesn't have the ability to slow him down. USC has been leaking points while engaging in shootouts all season, and I don’t expect that to change against the visiting Huskies.

At the same time, USC also has a quarterback capable of putting the team on his back and going out and winning a game almost single-handedly. Williams' season hasn’t quite gone according to plan, and he has appeared disoriented under pressure on multiple occasions, but the talent is still very much there and he has also shown that he can bounce back from a poor performance.

USC’s 48-20 loss at Notre Dame on Oct. 14 included what was probably the worst performance we have seen from Williams. In that game, he threw three early interceptions that ultimately put the score out of reach in a nightmare loss for his team.

His big bounce-back game came against Cal last Saturday, when Williams threw for 369 yards and two touchdowns. There will be no better time for him to prove himself than on Saturday against a fellow Heisman-contending quarterback. It’s a duel that could go down as one of the true highlight games of the 2023 college football season.

Washington ranks 110th in the country in terms of passing yards allowed to opponents, so expect an offensive showing and something of a quarterback master class in what should be a thriller on Saturday night.

Washington vs. USC Predictions and Pick

The unbeaten Huskies are playing for a shot at the national championship here. They’re ranked No. 5 in the nation going into this game, and a win over USC would help make their case when it comes to selections for the four-team playoff.

USC, on the other hand, will be hoping to rewrite its own story with a statement win toward the end of its season. The Trojans’ defense has let them down this year, and head coach Lincoln Riley’s team certainly hasn’t reached the heights many expected of them. Avoiding a third loss would certainly aid the Trojans’ momentum, and taking out Washington would give the program a much-needed boost.

Having said that, I think the Huskies will win this one by a touchdown. Quarterback Michael Penix has been carving up defenses with his offensive weapons this season, and we have seen time and time again that the Trojans just aren’t up to defending against an offense like this one.

There will be a ton of points and several lead changes, but I think Penix and the Huskies take this game.

The Pick: Washington Huskies -4 (-110)

College Football Schedule Week 10 – Game info - LSU at Alabama

College Football Season 2023
LSU (6-2) vs. Alabama (7-1)
Date: Saturday, Nov. 4
Time: 7:45 p.m. ET
Venue: Bryant-Denny Stadium in Tuscaloosa, Ala.
TV Channel: CBS
Live Stream: FuboTV

LSU vs. Alabama Odds, Spread, Over/Under, Moneyline - College Football Odds Week 10

Moneyline: LSU +135, Alabama -165
Spread: LSU +3 (-105), Alabama -3 (-110)
Total: Over/Under 59.5 

LSU vs. Alabama Preview

ESPN’s College Gameday heads to Tuscaloosa, Ala., this weekend for a very enticing SEC matchup between the LSU Tigers and Alabama Crimson Tide.

LSU has the nation's No. 2 offense in terms of points per game, as the Tigers are currently putting up an average of more than 43 this season. Their quarterback, Jayden Daniels, has 25 passing touchdowns, which ties him with USC’s Caleb Williams for the national lead. Daniels, who also has five rushing TDs, is enjoying the best season of his college football career as a fifth-year senior, and his sights are firmly set on the opportunity to be a high pick in next spring’s NFL Draft. Going into Bryant-Denny Stadium and coming away with a win would really put a big exclamation point on what has been a great season for him. He’ll have a chance to do just that against an Alabama team whose 2023 season has been a rather rocky ride so far.

While Alabama has struggled to rediscover itself offensively this season, LSU hasn’t missed a beat. The Tigers have put up 110 points over their last two games, and their playmakers have really shown up this year for what has been one of the country’s most impressive offenses in 2023.

LSU wide receiver Malik Nabers is destined for the NFL, and his 981 receiving yards and nine touchdowns this season are proof of that. He is an explosive route runner who can be a difference-maker at all three levels. He is also perfectly complemented by fellow receiver Brian Thomas Jr., who leads the team with 11 touchdown catches this year.

If the Tigers get Daniels going as a runner in this game, it’s going to give them a huge advantage. If Alabama can’t stop Daniels, I suspect LSU will just keep using him as a rusher. The Tigers’ triple option on offense is key here. When LSU is able to establish its ground game both with Daniels and running back Logan Diggs, the rest of its offense becomes that much more effective.

No team wants to find itself having to pack the box just to slow down LSU’s run option, only to leave its boundary corners in one-on-one situations defending against some of the best wide receivers in the SEC.

Alabama head coach and college football legend Nick Saban was tearing his hair out with this roster early in the season, but the Crimson Tide still find themselves at 7-1, despite what has felt like adversity all season.

Whether it has been lackluster offense, turnovers, close games against SEC opponents, or penalties, Alabama has certainly endured an off-year in multiple areas. The Tide scraped past Texas A&M with a 26-20 victory on Oct. 7 before battling through an even closer 24-21 win over Arkansas the following week after having entered that game against the Razorbacks as a 19-point favorite. 

Despite all of this team’s woes, the bottom line is that Alabama has made it to November with just one loss. This is still a top 10 team (No. 8 in the current AP poll) and its still has a shot at reaching college football’s playoffs. A win over LSU’s explosive offense would be huge for Alabama, and it's certainly possible for the Tide to achieve it if they can control the game.

Alabama quarterback Jalen Milroe has a rocket for an arm and he has settled into his offense more comfortably as the season has progressed. Milroe had seven touchdown passes and only two interceptions over the past three games, and he also ran for a TD. He can be dangerous when he’s at the top of his game, and he does have a shot at a big day against LSU’s subpar pass defense.

The Tigers’ secondary is banged up, and it will be missing multiple starters due to injury. That fact certainly works in Alabama’s favor, because we have already seen how the Tide’s offense can launch a touchdown out of nowhere to blow a game wide open. 

Alabama needs to take care of the football and limit its exposure defensively against the LSU offense. Saban’s players don’t want to find themselves in a shootout with a team that is averaging 50 points per game over the last couple of weeks, because that’s when things will start to unravel.

LSU vs. Alabama Predictions and Pick

Ultimately, this game is going to come down to a lot of offense, but LSU is in a much better situation than the Crimson Tide right now. The Tigers’ offense is far more established with more dangerous weapons. LSU quarterback Jayden Daniels is having a career year. He knows the SEC, and this could be a career-highlight game for him if things go right.

I have the Tigers going into Tuscaloosa and winning on the road to make their case for an outside shot at the playoffs. Look for LSU to take down Alabama on the Tide’s own field.

The Pick: LSU Moneyline (+135)

Odds are subject to change* 

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