College basketball’s regular season is drawing toward a close with conference tournament play just three weeks away. Right after that is Selection Sunday, and the NCAA Tournament selection committee has already released a top 16 early-seeding picture. Getting that information out in February provides teams on the March Madness bubble -- and those just on the outside looking in – with a little extra motivation for their final games. With a great slate of matchups set for Wednesday night, let’s dive in and see which four catch my eye as the best wagering opportunities.

Best College Basketball Parlays Today - Wednesday, Feb. 21: 4-Leg Parlay Picks (+341)

No. 16 Dayton vs. George Mason Prediction and Pick

The Dayton Flyers (21-4) have been amazing this season, led by DaRon Holmes II, a 6-foot-10 junior. Holmes is becoming one of the best big men in the country, and the Flyers have given him a great supporting cast. Junior forward Nate Santos is a good post partner for Holmes, while guards Kobe Elvis and Javon Bennett make up a solid backcourt. Very few teams have been a test for Dayton this season, as the Flyers have only four losses and should be a Sweet 16 contender or better during the NCAA Tournament. Wednesday’s opponent, George Mason, has also fared well this season at 17-8, but the Patriots will be no match for Dayton in this game. While GMU’s 6-6 Atlantic 10 Conference record hardly jumps off the page, the Patriots have been very competitive in those six A-10 losses. This won’t be an easy game for Dayton, but the Flyers will come out on top.

Leg-1 Parlay Pick: Dayton ML (-135)
No. 17 Kentucky vs. LSU Prediction and Pick

Heading into their game at South Carolina on Saturday, the LSU Tigers had gone only 3-7 in their previous 10 outings. That made their 64-63 road win over the No. 11 Gamecocks quite an upset. The win was a long time coming for the Tigers, who had nearly stolen a few victories against tough SEC competition during their 10-game slump. Unfortunately, the momentum LSU built up by beating South Carolina is going to end on Wednesday when the Tigers face No. 17 Kentucky (18-7) at home. So much for all that excitement suddenly brewing in Baton Rouge. Kentucky has gone up against a lot of talented teams this season, and the Wildcats have shown that they can compete with – as well as beat -- the best of them. This isn’t a letdown moment for Kentucky – it’s a momentum-boosting moment because this game will likely get out of hand quickly.

Leg-2 Parlay Pick: Kentucky ML (-275)
No. 22 Colorado State vs. New Mexico Prediction and Pick

I really hope the NCAA Tournament’s selection committee gives the Mountain West Conference the respect it deserves next month. There are a lot of talented players performing in the Mountain West this season, and a several of its teams could make some noise during March Madness. One of those teams is the New Mexico Lobos (20-6), who are going for revenge on Wednesday night against conference rival Colorado State (20-6). On Jan. 2, the Rams beat the visiting Lobos 76-68. That was a tough loss for New Mexico, which has a top-tier offense that ranks 13th in all of college basketball. Unfortunately, that scoring prowess disappeared for most of the second half in the game at Fort Collins, enabling the home team to pull away for the win. This time, however, New Mexico has the home-court advantage, and on Wednesday night the Lobos will show why they won’t just be playing in the NCAA Tournament – they will be making a run there. Look for New Mexico’s talented starting five of Jaelen House, Donovan Dent, Jamal Mashburn Jr., JT Toppin, and Nelly Junior Joseph to make a statement at the Pit on Wednesday. Don’t forget that this Lobos team is loaded with NBA and former college players’ family members.

Leg-3 Parlay Pick: New Mexico ML (-300)
UNLV vs. Air Force Prediction and Pick

As I mentioned above, the Mountain West Conference is going to make some noise during March Madness if the tournament’s selection committee holds up their end of the bargain by letting several Mountain West teams participate. UNLV is on the outside looking in as far as its NCAA Tournament potential, but a commanding road victory Wednesday and strong finish to the Rebels’ regular season could earn them a spot in the big dance. On Wednesday, UNLV (14-10) visits Air Force (8-16), a team that routed the Rebels 90-58 on Jan. 23 at Las Vegas. I know it might seem tempting to wager on Air Force to win again outright -- or at least take the Falcons and the points -- but trust me when I say that Jan. 23 was a fluke game for Air Force. Not only was it the only time the Falcons scored 90 points this season, it was also their only Mountain West win in 2023-24. The Air Force team isn’t good, and UNLV will get revenge at home on Wednesday night. Look for the Rebels’ Boone twins, seniors Kalib and Keylan, to shine in this game. Also look for junior forward Rob Whaley Jr. to set the tone down low and senior guard Luis Rodriguez to control the tempo with freshman guard Dedan Thomas Jr. providing points out of the backcourt. UNLV will take care of business on Wednesday and begin its final push for an NCAA Tournament berth.

Leg-4 Parlay Pick: UNLV ML (-200)

NCAAB PARLAY PICKS @(+341 odds): Bet $100 to Win $441.55

Bet on NCAAB Odds at Betway

Find season long NCAAB odds on the Betway. You'll find all the latest spreads, totals, money lines and over/under. Missed tip off? No problem, Betway also offers live betting. All your NCAAB betting needs are covered at our online sportsbook.