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Columbus Crew to beat Nashville (+100)

Columbus is one of just five teams in the MLS with an unbeaten record intact.

The Crew have won both of their home games and are second in the Eastern Conference, having taken eight points from four matches.

Nashville is third-bottom of the Western Conference and has taken one point from their last three games on the road.

LAFC to beat Orlando City (+170)

LAFC has the best record of any team in the MLS, having won three and drawn one of its opening four matches.

Bob Bradley’s team already beat Inter Miami in their only away game of the season so far and can make it two from two at a big price here.

Orlando lost 2-0 at home to strugglers Cincinnati in its last home game.

Philadelphia Union to beat Charlotte (-200)

Philadelphia is top of the Eastern Conference of the MLS with three victories and a draw from four matches.

Each of those three victories have come in the Union’s last three matches.

Charlotte has lost both games on the road this season against Atlanta United and DC United.

Minnesota United to beat Seattle Sounders (+125)

Minnesota United’s 1-0 victory at home to San Jose Earthquakes in their last match left them third in the Western Conference.

Adrian Heath’s team are unbeaten after four matches and come into this game after back-to-back victories.

Seattle is fourth-bottom of the Western Conference after losing two and drawing one of its opening four matches.

Vancouver Whitecaps to beat Sporting KC (+180)

Vancouver Whitecaps have had a difficult start to the season, losing three out of four, but can turn it around this weekend.

Each of the Whitecaps’ defeats have come on the road, while their only point came in a goalless draw at home to 2021 MLS Cup champions New York City in March.

Sporting KC have lost three games out of three on the road in 2022.

*Odds subject to change.