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Best NFL Parlay Picks today for Week 10: 4-Leg Parlay Pick (+1200)

Leg-1 SGP Pick: Indianapolis Colts -1.5 (-110)

Leg-2 SGP Pick: Commanders vs Seahawks Over 45.5 Points (-115)

Leg-3 SGP Pick: Detroit Lions -2.5 (-110)

Leg-4 SGP Pick: Arizona Cardinals +1.5 (-110) 

NFL SGP @(+1200): (Bet $100 to Win $1300). Get the best odds at Betway Sportsbook.

Best NFL Bets Week 10: Picks, Predictions & Schedules

NFL Schedule Week 10 – Game info - Patriots at Colts

2023 NFL Regular Season Game
New England Patriots (2-7) vs. Indianapolis Colts (4-5)
Date: Sunday, Nov. 12
Time: 9:30 a.m. ET
Venue: Deutsche Bank Park in Frankfurt, Germany
TV Channel: NFL Network
Live Stream: fuboTV, NFL+

Patriots vs. Colts Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 10

Moneyline: New England Patriots +100, Indianapolis Colts -120
Spread: Patriots +1.5 (-110), Colts -1.5 (-110)
Total: Over/Under 43.5 points

Patriots at Colts Preview 

The New England Patriots are in a pretty difficult spot, and it’s not looking like it will get much better anytime soon. They have now lost five of their last six games and are averaging just over 15 points per game, which ranks them second-to-last in the NFL. Only the New York Giants have had more trouble scoring.

Like the Giants, New England lacks any real offensive weapons. That fact becomes more glaringly obvious with each passing week. 

Wide receiver Kendrick Bourne was looking like the Pats’ best bet this season, but he will now miss the remainder of the year with a torn ACL. That leaves the team’s No. 1 receiver role to rookie Demario Douglas, a sixth-round draft pick.

JuJu Smith-Schuster has failed to make an impact in New England, and the Patriots’ decision to let Jakobi Meyers walk out the front door is really not looking like a good move at the moment. Legendary coach Bill Belichick undoubtedly failed to draft or sign a difference-maker on offense, leaving quarterback Mac Jones with only late-round draft picks and free agents as targets.

Jones might not be the perfect answer at quarterback for this team, but he also isn’t the problem.

I’m not sure he would get “fired,” but Belichick does appear to be on the hot seat right now. Some in the media are reporting that Sunday’s game in Germany has become a must-win situation when it comes to the coach’s future with his team. We have no idea if any of those rumors are true, but there’s no doubt that this is a critical game for a 2-7 Patriots team.

Indianapolis has also had struggles this year. The biggest problem for the Colts is that they have been forced into starting Gardner Minshew at quarterback since a shoulder injury cut star rookie Anthony Richardson’s season short.

Minshew is one of the better NFL backup QBs, but at this point in the season, I suspect that we know what the Colts are going to be. They will have some good weeks offensively -- supported by a defense capable of forcing turnovers – but they are also going to have bad weeks.

Indianapolis averages almost 26 points per game, which ranks among the best teams in the NFL, but Minshew has only thrown eight touchdown passes this year. Indy finds its success with a 1-2 punch on the ground. The Colts use running backs Jonathan Taylor and Zack Moss to spark the offense, and that strategy is working.

Patriots vs. Colts Predictions and Pick

This feels like it is the Colts’ game to lose, and Indianapolis’ defense is going to enter this weekend with a lot more confidence following last Sunday’s performance in a 27-13 win at Carolina. Cornerback Kenny Moore had two pick-sixes in what turned into a three-interception and four-sack day for the Colts defense.

With Patriots QB Mac Jones struggling to find guys who can get open with any regularity, I like the Colts to pull away in this one.

The Pick: Indianapolis Colts -1.5 (-110)

NFL Schedule Week 10 – Game info - Commanders at Seahawks

2023 NFL Regular Season Game
Washington Commanders (4-5) vs. Seattle Seahawks (5-3)
Date: Sunday, Nov. 12
Time: 4:25 p.m. ET
Venue: Lumen Field, in Seattle, Wash.
TV Channel: FOX
Live Stream: fuboTV, NFL+

Commanders vs. Seahawks Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 10

 Moneyline: Washington Commanders +225, Seattle Seahawks -275
Spread: Commanders +6.5 (-115), Seahawks -6.5 (-105)
Total: Over/Under 45.5 points

Commanders at Seahawks Preview

The Seattle Seahawks faced a pretty ugly demise last weekend, losing to the Ravens 37-3 at Baltimore. While Seattle was not the first team to suffer such a fate at M&T Bank Stadium this season, that loss doesn’t bode well for a franchise hoping to make run in the upcoming playoffs.

The loss left Seattle at 5-3, tying the Seahawks with the San Francisco 49ers for first place in the NFC West. Correcting their errors and picking up a home win over the Washington Commanders on Sunday feels it will be critical to the team’s season. Seattle still has big games coming up against Dallas and Philadelphia as well as a pair of division games against the 49ers.

While Seahawks quarterback Geno Smith has shown flashes of high-level play this year, he doesn’t appear to be competing with the same killer instinct that he displayed last season. Smith’s 2022 performance earned him a three-year, $75 million contract over the summer, but at the midpoint of this season, he has thrown for a total of only nine touchdowns. Smith is also one of the most pressured QBs in the league this year, which has certainly contributed to some of his inconsistency. 

On the flip side, Seattle's ground game is thriving. Running back Kenneth Walker has 532 rushing yards and six touchdowns this season to rank seventh among the NFL’s yardage leaders. He could have a major impact on this game against a Commanders team that just parted with two of its best defensive linemen prior to the NFL trading deadline.

Overall, Washington’s defense has struggled this year, particularly against good passing offenses. The Commanders allow 252 passing yards per game, which ranks in the NFL’s bottom six. They have also allowed at least 33 points on five separate occasions this season. 

Quarterback Sam Howell and the high-volume Washington offense have been holding the Commanders up, as the young, second-year quarterback might just be the real deal.

Howell currently ranks second in the league for total passing yards this season, and only Miami Dolphins quarterback Tua Tagovailoa has more. The Commanders QB is dropping back a lot and has thrown for a total of more than 700 yards over the past two games alone.

Washington seems perfectly content in allowing its young quarterback to throw the football. Howell has dropped back to pass at least 50 times in four of the eight games he has played this season.

Wide receiver Terry McLaurin’s relationship with his new quarterback is budding, too. McLaurin has had at least five catches in each of his last four games. The Commanders WR1 is on pace for his fourth straight 1,000-yard season, and his biggest year yet in terms of total receptions. 

Commanders vs. Seahawks Predictions and Pick

I believe we will see an offensive game here, since both teams are capable of scoring a ton of points. Seattle running back Kenneth Walker should be able to produce on the ground and will likely score at least once, which should open things up for QB Geno Smith to throw the football.

Washington quarterback Sam Howell also certainly understands that his team needs him to put points on the board. The Seahawks and Commanders’ defenses both allow more than 230 passing yards per game. These teams also have a combined average of over 49 points allowed per game, so I’ll take the over in what could be a back-and-forth contest.

The Pick: Over 45.5 Points (-115) 

NFL Schedule Week 10 – Game info - Lions at Chargers

2023 NFL Regular Season Game
Detroit Lions (6-2) vs. Los Angeles Chargers (4-4)
Date: Sunday, Nov. 12
Time: 4:05 p.m. ET
Venue: SoFi Stadium in Inglewood, Calif.
TV Channel: CBS
Live Stream: fuboTV, NFL+

 Lions vs. Chargers Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 10

Moneyline: Detroit Lions -135, Los Angeles Chargers +115
Spread: Lions -2.5 (-110), Chargers +2.5 (-110)
Total: Over/Under 48.5 points

Lions at Chargers Preview

If you are looking to watch a thriller from a neutral-fan’s standpoint this weekend, then I have to imagine that this would be your game. These two offenses are both capable of explosive drives, big yardage, and a lot of points. Each will be going up against a defense that has allowed plenty of those things so far this season.

Detroit bounced back from its dreadful Oct. 22 loss at Baltimore with a relatively comfortable Monday night win over the Las Vegas Raiders before entering its bye week. The Lions will now return fresh and ready to face the Chargers on Sunday afternoon.

The break will have allowed the Lions the chance to get healthy, since players such as wide receiver Amon-Ra St. Brown had been dealing with nagging injuries prior to the bye week. 

Lions running back David Montgomery, center Frank Ragnow, and guard Jonah Jackson all missed the Oct. 30 game against the Raiders due to various injuries, but all three have been back at practice this week and are expected to suit up on Sunday. In fact, as of Wednesday, the Lions hadn’t had a single player miss practice this week, which means this team is about as healthy as it can be at this point in the season.

On Monday night, the Los Angeles Chargers scored a much-needed win over the New York Jets, but quarterback Justin Herbert is still heavily bandaged on the middle finger of his non-throwing hand. The fracture he suffered against the Raiders in Week 4 is extremely painful, but Herbert continues to play through it, and he will need his best stuff to keep up with a high-flying Lions offense this weekend. 

Both defenses have struggled against the pass this year. The Chargers rank dead last in pass-defense efficiency, allowing a league-high average of 286 passing yards per game. Detroit is allowing 220, and both teams give up an average of more than 20 points per game.

With so much offensive talent on display from both teams, I am expecting fireworks and plenty of touchdowns.

Lions vs. Chargers Predictions and Pick

Detroit's offense has only been silenced only once this year, and that happened on the road against a Ravens team that just did the exact same thing to the Seattle Seahawks. I believe that uncharacteristic game for the Lions was more about the strength of the Ravens’ defense than any flaws in the Lions’ offense.

This weekend, Detroit will be facing the NFL’s worst pass defense with unproven corners and plenty of space for the likes of wide receiver Amon-Ra St. Brown and tight end Sam LaPorta.

The Chargers’ offense is dangerous, too, although perhaps less diverse -- particularly since wide receiver Josh Palmer is battling injuries. If either fellow receiver Keenan Allen and running back Austin Ekeler do not have game-winning-level days with an inspired performance from Justin Herbert, then Jared Goff and the Lions will win this one on the road.

Detroit is 6-2 against the spread this season. We picked the Lions to cover in their last game, and I expect them to cover and win again this week.

The Pick: Detroit Lions -2.5 (-110)

NFL Schedule Week 10 – Game info - Falcons at Cardinals

2023 NFL Regular Season Game
Atlanta Falcons (4-5) vs. Arizona Cardinals (1-8)
Date: Sunday, Nov. 12
Time: 4:05 p.m. ET
Venue: University of Phoenix Stadium, in Glendale, Ariz.
TV Channel: CBS
Live Stream: fuboTV, NFL+

Falcons vs. Cardinals Odds, Spread, Moneyline, Over/Under - NFL Betting Lines Week 10

Moneyline: Atlanta Falcons -120, Arizona Cardinals +100
Spread: Falcons -1.5 (-110), Cardinals +1.5 (-110)
Total: Over/Under 42.5 points

Falcons at Cardinals Preview

The obvious storyline here is the more than likely return of Cardinals quarterback Kyler Murray. who will be making his first start of the season on Sunday afternoon. Murray, who hasn’t played since Week 14 of last year, had been enduring the inevitable long and grueling recovery from a torn ACL.

The Cardinals made the decision to part with QB Josh Dobbs prior to the NFL trading deadline -- sending him to Minnesota as part of a pick swap. It seemed a strange decision to deal Dobbs away rather than keep him on as a backup quarterback, particularly since last Sunday’s performance by rookie Clayton Tune didn’t help to ease anyone’s concerns. 

In Tune’s defense, he was thrown out onto the field with very few weapons against one of the best coverage defenses in football, but his 58-yard, two-interception stat line was far from ideal.

Arizona will now hope that Murray can remain healthy and perhaps deliver a couple more wins before the end of the season. This franchise is currently in the pole position for the NFL’s No. 1 overall draft pick in 2024, which creates an interesting dynamic with Murray back at QB for the remainder of the season.

If he helps his team win games going forward, Murray would also likely reduce the possibility that Arizona would be in position to draft Caleb Williams and trade Murray to another NFL team in the offseason. If he doesn’t win any games, that outcome would be very likely.

Atlanta enters this game at 4-5, just one game behind the New Orleans Saints in a wide-open NFC South Division. Either the Falcons, Saints, or Tampa Bay Buccaneers could end up winning the division, and this weekend offers Atlanta head coach Arthur Smith’s team a major opportunity to claim a victory on the road. 

Like the Cardinals, the Falcons haven’t had the smoothest sailing at their quarterback position. Initial starter Desmond Ridder has been benched in favor of veteran Taylor Heinicke, who has looked average at best in the two games he has played.

Atlanta continues to make strange decisions offensively, refusing to involve tight end Kyle Pitts at all and taking carries away from running back Bijan Robinson in the very situations in which he has been at his best. Tight end Jonnu Smith had a great day in last weekend’s 31-28 loss to the Vikings with five catches for 100 yards and a touchdown, but I can’t help question Arthur Smith’s utilization of all the talent available to him.

Earlier in the season, the Falcons’ defense was proving to be Atlanta’s best weapon, but that defense has now allowed 28 or more points in consecutive games. A fourth-quarter meltdown against Dobbs, who was making his first start for the Vikings, didn’t help matters. One week earlier, Atlanta allowed Tennessee rookie Will Levis to throw for 238 yards and four touchdowns in his first career start for the Titans.

Falcons vs. Cardinals Predictions and Pick

If he is comfortable and displays very little rust, then Arizona’s Kyler Murray will easily be the best quarterback on the field. He should be able to put the Cardinals in a position to win.

This Arizona team has desperately needed a boost, and Murray’s return to the lineup gives it just that. The Cardinals might also have running back James Conner available, since his 21-day practice window was opened on Wednesday. 

While they have had some nightmarish games and only one win this season, the Cardinals have also covered the spread in four of their nine games. They only lost to the Ravens by seven points at home, and I think this is a very winnable game for them on Sunday. 

The Pick: Arizona Cardinals +1.5 (-110)

Odds are subject to change*  

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