Visit Betway’s NFL picks page for picks and predictions throughout the season.

Derrick Henry rushing yards: Over 97.5 -110

This season, Derrick Henry has started most games slow and inefficient. However, the Titans stay committed to the run, continuing to feed Henry throughout the entire game. This helps to wear down the defense and get him going. The result is him running for 113 or more yards in four straight games.

Buffalo hasn’t faced any rushing attack you’d fear this season, so it’s possible the physicality of Tennessee catches them a bit off guard.

Devin Singletary rushing yards: Over 24.5 -115

While Zack Moss has returned to the lineup and impressed, Devin Singletary has continued to be the Bills’ starter. He has totaled double-digit carries in all but one game this season.

If we assume he gets back to at least 10 carries, then Singletary would only need to average 2.5 yards per carry to hit the over. However, he has averaged 5.2 yards per carry this season, and has ran for 25+ yards every single game.

Josh Allen passing yards: Over 292.5 -110

After the Bills were surprisingly beaten in Week 1, they have been dominant, as has their quarterback. Josh Allen has been so dominant that he has been able to take his foot off the pedal a bit.

He beat Miami 35-0 and Houston 40-0, which were two games in which he passed for under 250 yards. However, the other two games were more competitive, and he averaged 336.5 yards in those matchups.

While the Bills are expected to win tonight, Tennessee should keep it competitive, which points to Allen passing for over 300 yards again. The fact that the Titans allow 7.9 yards per pass attempt, which is the fifth-worst in the NFL, also helps this prop.

Ryan Tannehill rushing yards: Over 15.5 -110

We have seen Ryan Tannehill run for 17 or more yards in four of his five games this season. Overall, he has averaged 26 rushing yards per game thisyear.

Tonight, the Titans are projected to be playing from behind. This would mean more drop-backs for Tannehill, leading to more opportunities for him to scramble and pick up yards with his legs.