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There have been a lot of great NFL comebacks, but only five can make the list. These are the greatest comebacks in NFL history.

1. New England Patriots vs. Atlanta Falcons | Super Bowl LI | 2017 | NRG Stadium, Houston 

The game will likely go down as the biggest collapse in modern-day sports history. Everything went right for the Falcons in the first half as they led the Patriots 21-3 at halftime, and the Patriots looked deflated coming out of the locker room. It seemed like the game was over in the third quarter as they went 28-3 down, but a miraculous 25-point comeback was led by Patriots quarterback Tom Brady, along with some key plays by the Patriots defense.

Patriots wide receiver Julian Edelman made one of the greatest catches in NFL history with 2:23 left in the fourth quarter, before the Patriots tied the game at 28-28 to send it to overtime. At this point, the Patriots had all the momentum they needed to secure the biggest comeback in Super Bowl history, and a little bit of luck was on their side as they won the coin toss and marched down the field to score the game-winning touchdown. The touchdown was scored by running back James White, who will forever be remembered by Patriots fans after he helped secure the franchise's fifth Super Bowl.

2. Buffalo Bills vs. Houston Oilers | AFC Wild Card | 1993 | Orchard Park, New York

Twenty-nine years ago, the biggest comeback in NFL history took place. Yes, you heard that right.

The Buffalo Bills were down by 32 at one point, and it looked like their run of back-to-back Super Bowl appearances was coming to an end. But backup quarterback Frank Reich and the Buffalo defense got the stops they desperately needed to make this comeback possible.

The Bills scored 35 unanswered points to take a 38-35 lead with 3:08 left in the fourth quarter. It wasn’t quite over, though, with the Houston Oilers kicking a game-tying field goal to send the game into overtime. Luckily for the Bills, the Oilers couldn’t capitalize in the extra period and secure the victory. Oilers quarterback Warren Moon threw a costly interception to cornerback Nate Odomes, before a facemask penalty and the return from Odomes set up the Bills in great field position on the 20-yard line. Bills kicker Steve Christie then kicked a 32-yard game-winning field goal to seal the comeback and send Buffalo into the Divisional Round.

3. San Francisco 49ers vs. Detroit Lions | Western Conference Championship Game | 1957 | Kezar Stadium, San Francisco

During the 1957 Western Conference championship game, the Niners held a convincing 24-7 lead at halftime over the Detroit Lions at Kezar Stadium. The 49ers were so confident of the win that the Lions players heard them laughing about the 17-point lead in the locker room during the break.

Early in the third quarter, the Niners extended their lead to 27-7 by kicking a field goal, but didn’t score another point after that. The Detroit Lions' backup quarterback, Tobin Rote, led his team to an amazing comeback, one that nobody expected, as they scored 24 unanswered points to upset the 49ers. Detroit then went on to beat the Cleveland Browns 59-14 to win their first championship in franchise history.

4. Indianapolis Colts vs. Kansas City Chiefs | AFC Divisional Round | 2014 | Lucas Oil Stadium, Indianapolis

Eight years ago, Colts quarterback Andrew Luck led his team from 38-10 down early in the third quarter to an incredible win. After scoring 21 points to close the gap to 41-31 entering the fourth quarter, the Colts put together an impressive 90-yard drive that ended with an insane play. Running back Donald Brown fumbled the ball, it bounced off center Samson Satele, and Andrew Luck grabbed the ball before diving into the end zone from five yards out to cut the Chiefs lead to 41-38.

The Colts then went ahead with 4:21 left in the fourth quarter thanks to a 64-yard pass from Luck to wide receiver T.Y. Hilton. Hilton had an all-time great performance, finishing the game with 13 catches for 224 yards and two touchdowns. On the next drive, the Colts' defense got the stop they needed against Alex Smith and sealed the deal. 

5. San Francisco 49ers vs. New York Giants | NFC Wild Card | 2003 | Candlestick Park, San Francisco

A remarkable comeback from the 49ers on January 5, 2003, saw them come back to win the game 39-38 after being down 24 points. During the third quarter, the Giants led the 49ers 38-14, and Giants tight end Jeremy Shockey dropped a touchdown pass that would have increased the lead to 31 points. The 49ers then kicked a field goal before quarterback Jeff Garcia completed two touchdown passes and ran for another to take a one-point lead with one minute left in the fourth quarter.

Giants quarterback Kerry Collins then marched his team down the field to the 23-yard line, where they attempted a field goal with six seconds left on the clock. The Giants' worst mistake came when the snap was low and holder Matt Allen attempted a pass to guard Richard Seubert, who was tackled by 49ers linebacker Chike Okeafor. Rather than being penalized for pass interference, the Giants were penalized for having an ineligible receiver downfield, and that was the game.