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It’s a big week for college football, with the elephant in the room being the huge game between the Georgia Bulldogs and the Tennessee Volunteers. The No. 1 team in the nation meets the No. 2 team in what will be a major test of both team’s bottle against what is likely to be playoff competition.

Alabama faces LSU while Clemson goes on the road to face Notre Dame, and Oklahoma State will want to bounce back after an embarrassing defeat against Kansas State in which they got shut out. The Cowboys will go on the road to face the Kansas Jayhawks, who have lost three in a row after a 5-0 start to the season.

It’s a fun week of college football, headlined by the Georgia vs Tennessee game, which we will get to later. Without further ado, here are my favorite picks for this Saturday's college football slate.

Best College Football Bets Week 10: Picks, Predictions & Schedules

College Football Schedule Week 10 – Game information - No. 6 Alabama Crimson Tide @ No. 15 LSU Tigers

College Football Season 2022 Game

Alabama vs LSU

Date: 5 November 2022

Time: 7:00pm EST

Venue: Tiger Stadium - Baton Rouge, Louisiana

TV Channel: ESPN

Live Stream: fuboTV

Live Radio: AM 790 in Tuscaloosa, WDGL-FM ("The Eagle 98.1") in Baton Rouge

Alabama vs LSU Odds, Spread, Over/Under, Moneyline - College Football Odds Week 10Moneyline: Alabama Crimson Tide -520, LSU Tigers +380

Spread: Alabama -13, LSU +13

Total: Over/Under 56.5

It had been an unpleasant couple of weeks for the Crimson Tide, who suffered a loss to the Tennessee Volunteers that saw them drop out of the top four in the rankings and down to No. 6. It marked the biggest scoring game against any Alabama team in over 100 years, and the Tide needed to right the ship the following week against Mississippi State.

While they did that, the win against the Bulldogs was not their strongest performance, and they’ll need to find form against LSU if they want to be frontrunner for the SEC West title this season.

The Tigers might be the underdog, but recent film on the Crimson Tide will have teams believing they’re beatable. The Tigers have scored 45 in their last two, both wins against Florida and Ole Miss, and won’t be pushovers on their home field against the Tide.

Alabama vs LSU Predictions and Picks

Will Anderson, edge rusher for the Tide, has been one of the biggest names in college football for two seasons now. There are Bama fans who claim he might be the best defensive player during Nick Saban's tenure as the head coach, which is saying something considering the amount of talent the Tide have funnelled into the NFL during that time.

Anderson is a game wrecker coming off the edge, and LSU are starting two freshman offensive tackles this weekend. That’s a mismatch, and I think the edge Anderson gives the Tide could be a major factor in the game.

Bama struggled in the run game against Mississippi State, with Jahmyr Gibbs averaging just 3.7 yards per carry on 10 attempts. He has been a key piece for the Tide in recent weeks but was quiet last time out. LSU allowed over 200 yards rushing against the Florida Gators a couple of weeks back, and if they can’t control Gibbs, the game could fall apart as the pass game opens up for Bryce Young.

I do believe LSU will put up a strong fight at home, but can see Alabama putting this one away with a dagger touchdown late that puts the Tigers in the rear view. Bama to clear the spread.

The Pick: Alabama Crimson Tide -13 (-110)

These are two scoring offenses. I’ve been impressed with the Tigers' scoring ability in their last two SEC games. Jayden Daniels had five all-purpose touchdowns against Ole Miss, including three rushing on over 100 yards on the ground. Alabama will need to contain him to clear the spread, which I think they’re capable of to an extent, but Daniels and the offense are still likely to put up some points.

I like the over for the game, with explosive plays a major factor and quick scoring drives resulting in the game clearing the 58-point oddsmakers line.

The Pick: Over 56.5 Points (-110)

College Football Schedule Week 10 – Game information: Texas Longhorns @ No. 13 Kansas State Wildcats

College Football Season 2022 Game

Texas vs Kansas State

Date: 5 November 2022

Time: 7:00pm EST

Venue: Bill Snyder Family Stadium - Manhattan, Kansas

TV Channel: FOX

Live Stream: fuboTV

Live Radio: Longhorn IMG Radio Network/104.9 The Horn (Austin Flagship); SiriusXM channel 158 or 200 and SXM App channel 954

Texas vs Kansas State Odds, Spread, Over/Under, Moneyline - CFB Odds Week 10Moneyline: Texas Longhorns -140, Kansas State Wildcats +120

Spread: Texas -3, Kansas State +3

Total: Over/Under 54.5 

Kansas State have documented a few impressive wins so far this season, with last Saturday's perhaps the greatest so far. The Wildcats shut out a 6-1 Oklahoma State team that had scored 40 points in each of their last three outings. Running back Deuce Vaughn was running away from the defense all day, finishing with 158 yards on the ground and a touchdown while averaging 7.2 yards per carry.

The Wildcats have beaten Oklahoma on the road and almost did the same thing to TCU had it not been for a poor performance in the second half. They host the Texas Longhorns this weekend, whose last game was a loss to Oklahoma State, the same team Kansas State just shut out for four quarters.

Texas comes into this one fresh off the bye week, and will hope to take better care of the football having turned the ball over three times in the loss to the Cowboys.

Texas vs Kansas State Predictions and Picks

Quinn Ewers' outing against Oklahoma State has me a little concerned as they head into Manhattan this weekend. He was 19/49 on the day throwing two touchdowns but three interceptions. He didn’t look good at all, and turning the ball over resulted in Oklahoma State annihilating the Longhorns secondary, with just shy of 400 passing yards.

Kansas State quarterback Adrian Martinez is day-to-day, but the Wildcats were just fine last weekend without him. Will Howard threw for 296 yards and four touchdowns with no turnovers against Oklahoma State, a performance from the Wildcats back up that far surpassed that of Ewers the week before against the same defense.

I like Kansas State here. The Longhorns haven’t traveled well and the Wildcats have played really well at home since the disappointing defeat to Tulane early in the season.

The Pick: Kansas State Moneyline (+120)

It's a tough over/under line on this one with both teams able to score a lot of points on their day, but both sides also showing strong defense. The Wildcats allowing zero points at home against an explosive offensive is obviously a factor in the decision making here, and I think they hold the Longhorns to 21 or less.

I’m banking on that strong defensive performance here, but I’ll take the under for the game in this one. Ewers has some work to do to correct his decision-making and build those relationships offensively, and while the bye week will lend a hand to those corrections, I’m not sure it’s enough time before this difficult road game.

The Pick: Under 54.5 Points (-110)

College Football Schedule Week 10 – Game information: No. 2 Tennessee Volunteers @ No. 1 Georgia Bulldogs

College Football Season 2022 Game

Tennessee vs Georgia

Date: 22 October 2022

Time: 3:30 pm EST

Venue: Sanford Stadium - Athens, Georgia

TV Channel: SEC Network

Live Stream: fuboTV

Live Radio: Sirius 91

Tennessee vs Georgia Odds, Spread, Over/Under, Moneyline - CFB Odds Week 10

Moneyline: Tennessee Volunteers +230, Georgia Bulldogs -290

Spread: Tennessee +8, Georgia -8

Total: Over/Under 66 

The very first official college football playoff rankings were released this week, and the Tennessee Volunteers were ranked No. 1. The ranking marked the first time since 1998 that Tennessee had been in the top spot, and just in time for them to visit the Georgia Bulldogs ranked right behind them.

Obviously in the AP poll, the two are ranked the other way around, so it’s all to play for in Athens on Saturday afternoon between this season's two most impressive college football outfits.

Tennessee vs Georgia Predictions and Picks

The Georgia Bulldogs might be 8-0 this season, but they’ve had a couple of close calls. They had to mount a fourth quarter comeback against Missouri, and allowed Florida to creep back into a game that they should have had wrapped up early.

They have, however, crushed Oregon in the opening game of the season, shut out both Samford and Vanderbilt, and beat South Carolina by 41 points. The question is which Bulldogs team is going to turn up on the day.

I do believe there will be periods of the game where the Bulldogs struggle to keep up with the attacking prowess of this Tennessee outfit. They will leak points at a higher rate than they have done in some games, and that applies pressure to Stetson Bennett and the Bulldogs offense.

Put it this way, Tennessee can hang in this game. They’re more powerful offensively than the likes of Florida and Missouri, and the Bulldogs let those teams drive on them during lapses in concentration in a four quarter game. That’ll be costly against Tennessee.

I’ll bank on the Vols applying some legitimate pressure and making this a very close game, even on the road. If Tennessee can get out in front, it’ll be a photo finish at the close of the 4th.

The Pick: Tennessee Volunteers +8 (-110)

Tennessee’s SEC matchups have been interesting too. They held LSU to 13, marking the Tigers' lowest scoring game of the season, and did the same to Kentucky, only allowing the Wildcats to score 6. They then allowed Florida to score 33, and gave up 49 in the Alabama game. So, which Tennessee defense shows up on Saturday?

There are question marks around the Vols ability to defend the pass. They’re allowing 300 passing yards per game, but keeping things pretty tight by avoiding big yardage gains after the catch. Points will be scored, but the Volunteers are capable of doing enough to hold Georgia to less than 30 points on their day. They just totally eliminated Will Levis’ arm against Kentucky, so we’ll see if they can pull off a similar fear against Stetson Bennett, who isn’t considered to be an elite passing talent.

Hendon Hooker is one of the best legitimate passing threats the Bulldogs will see this season, and while they rank second in the country for points allowed per game (10.5), this does not feel like one of those games. The match up between Hooker and his weapons against this Bulldogs secondary will be a key factor in the game.

I’ll be banking on a similar outcome to the Alabama game here, with a back and forth shootout resulting in around 70 points being scored. I do believe the Volunteers have a good shot at winning this game, so betting both their ATS line and the over for the game feels good to me. Tennessee will need to score 35+ if they want to put Georgia away.

The Pick: Over 66 Points (-115)