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Clyde Edwards-Helaire over 51.5 rushing yards (-110)

The Chargers give up 4.7 yards per carry, which is tied for the second-most in the NFL. Clyde Edwards-Helaire continues to serve as the lead back for the Chiefs, and he has run for over 51.5 yards in two of the three games since returning from injury. The one failed attempt was in the massive blowout last week.

In the first matchup against the Chargers this season, Edwards-Helaire ran for 100 yards on 17 carries. 

Clyde Edwards-Helaire under 2.5 receptions (-175)

The Chiefs will be using Edwards-Helaire much more in the running game than the passing game this week. For the season, he averages two receptions per game, which is the same amount that he had in the first matchup with the Chargers this season.

Los Angeles also gives up the fifth-fewest receptions to running backs in the league, at just over four per game. With Darrell Williams also getting snaps for Kansas City, all signs point to the under hitting for this prop. 

Patrick Mahomes under 2.5 passing touchdowns (-205)

The Chargers have had Mahomes’ number throughout his career. As well as holding him to lower yardage than usual, Los Angeles has kept him under 2.5 passing touchdowns in four of his past five matchups against them.

On top of that, Mahomes has topped 2.5 passing touchdowns just twice this season. 

Justin Herbert over 284.5 passing yards (-115)

The Chiefs have brought the best out of Justin Herbert in his young career. He has averaged 298 yards against them, which includes his impromptu first NFL start. The lowest passing yardage total he has had against Kansas City was 281, which came in a win.

Herbert has also passed for over 300 yards in three of his past four games. Considering he has averaged 295.5 passing yards in prime-time games, he should continue the trend.